About 32 results found for searched term "OX Receptor" (4.993 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21445 | Recombinant Human OLR1/LOX1 (Mammalian, C-6His) | Recombinant Proteins |
| Oxidized Low-Density Lipoprotein Receptor 1; LOX-1 | ||
| Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. | ||
| M29995 | OT-R antagonist 1 | Oxytocin Receptor |
| Oxytocin receptor antagonist 1 | ||
| OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). | ||
| M1859 | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M1880 | WY 14643 (Pirinixic Acid) | PPAR |
| Pirinixic Acid; NSC 310038 | ||
| WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. | ||
| M2033 | GSK 3787 | PPAR |
| GSK3787 | ||
| GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). | ||
| M2105 | Azilsartan medoxomil | Angiotensin Receptor |
| TAK-491 | ||
| Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. | ||
| M2349 | (R)-Nepicastat hydrochloride | HCV Protease |
| RS-25560-198 HCl | ||
| (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| M2134 | Vortioxetine hydrobromide | 5-HT Receptor |
| Lu AA21004 | ||
| Vortioxetine hydrobromide (Lu AA21004) is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro. | ||
| M2200 | Ciprofibrate | PPAR |
| Win35833 | ||
| Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist. | ||
| M2280 | Tamoxifen Citrate (ICI 46474) | Estrogen Receptor |
| ICI 46474; Istubal; Nolvadex | ||
| Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. | ||
| M2437 | Bazedoxifene hydrochloride | Estrogen Receptor |
| TSE-424 | ||
| Bazedoxifene hydrochloride is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM. | ||
| M2522 | Ciproxifan | Histamine Receptor |
| FUB-359 | ||
| Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. | ||
| M2619 | Deoxycorticosterone acetate | Animal Modeling |
| DOCA; 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate | ||
| Deoxycorticosterone acetate, an adrenocorticotropic hormone and also a precursor of aldosterone, as well as a salicorticoid receptor (MR) agonist, can be used to construct rat models of hypertension. | ||
| M2650 | Doxepin hydrochloride | Histamine Receptor |
| Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. | ||
| M2653 | Doxylamine Succinate | Histamine Receptor |
| Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. | ||
| M2760 | Hydroxyzine dihydrochloride | Histamine Receptor |
| Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. | ||
| M2822 | Loxapine Succinate | 5-HT Receptor |
| Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. | ||
| M2842 | Methoxamine hydrochloride | Adrenergic Receptor |
| Vasoxine HCl | ||
| Methoxamine is an α1-adrenergic receptor agonist, it induces vasoconstriction of skin and splanchnic blood vessels. | ||
| M2924 | Pentoxyverine Citrate | Sigma Receptor |
| Carbetapentane Citrate | ||
| Pentoxyverine citrate is an orally active sigma-1 receptor agonist with Ki values of 41 nM for σ1, 894 nM for σ2, and 75 nM for σ1 in guinea pig brain membranes.Pentoxyverine citrate is also a muscarinic antagonist. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M3043 | Synephrine hydrochloride | Adrenergic Receptor |
| Oxedrine hydrochloride | ||
| SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. | ||
| M3213 | Meclizine dihydrochloride | Histamine Receptor |
| Meclozine dihydrochloride; NSC28728 | ||
| Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. Phase2. | ||
| M3251 | Bazedoxifene Acetate | Estrogen Receptor |
| TSE 424; WAY-TES 424 | ||
| Bazedoxifene Acetate is a third generation, oral and nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. | ||
| M3256 | Eplerenone | Others |
| Epoxymexrenone | ||
| Eplerenone (Epoxymexrenone) is a selective, competitive and oral aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen, and glucocorticoid receptors. Eplerenone may be used in studies of hypertension and heart failure following myocardial infarction. | ||
| M3261 | Almorexant | OX Receptor |
| ACT-078573 | ||
| Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. | ||
| M3283 | Pioglitazone | PPAR |
| U 72107 | ||
| Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. | ||
| M3324 | SB408124 | OX Receptor |
| SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | ||
| M3401 | 5-hydroxymethyl Tolterodine | AChR/AChE |
| PNU 200577 | ||
| 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM. | ||
| M3511 | Olmesartan Medoxomil | Angiotensin Receptor |
| CS 866 | ||
| Olmesartan Medoxomil is a compound which is hydrolyzed to olmesartan that is a selective AT1 subtype angiotensin II receptor antagonist. | ||
| M3635 | FH535 | PPAR |
| FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. | ||
| M3760 | TCS-1102 | OX Receptor |
| TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). | ||
| M3777 | PF-3274167 | Others |
| cligosiban | ||
| PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. | ||
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